Dopo l'ennesima vittoria, però, alcuni giocatori decidono di impartirgli una lezione, dalla quale fugge con l'aiuto del fratello Tadashi.

Hiro Hamada è un giovane e geniale ragazzino di 14 anni, che la notte partecipa ai bot duelli (incontri clandestini dove gli sfidanti fanno combattere dei robot costruiti da loro stessi che si svolgono nei vicoli e nelle zone più malfamate della città) dove frequentemente vince, ottenendo notevoli vincite di denaro.

La storia si svolge nella frenetica e tecnologica città di San Fransokyo. Alastair Krei, renowned entrepreneur and president of Krei Tech, offers to buy the microbots, but Hiro follows Callaghan's warnings. Professor Callaghan, the head of the university's robotics program, is impressed, and grants Hiro entrance to the university. To enroll in the school, Hiro signs up for the school's science fair and presents microbots: swarms of tiny robots that can link together in any arrangement imaginable. To redirect Hiro, Tadashi takes him to the robotics center at his university, where Hiro meets Tadashi's friends: GoGo, Wasabi, Honey Lemon, and Fred, as well as Baymax, the healthcare companion robot Tadashi created. Raised by his aunt Cass and older brother Tadashi after the death of his parents, he spends his time participating in illegal robot fights.

Hiro Hamada is a 14-year-old robotics genius who lives in the futuristic fictional city of San Fransokyo.

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